Tumor involves 1 or both ovaries with cytologically or histologically confirmed spread to the peritoneum outside the pelvis andor metastasis to the retroperitoneal lymph nodes old. The reason for the high death rate is the late presentation in most cases, meaning that the disease is widely metastatic within the abdomen. Epithelial ovarian cancer is the fourth commonest cause of female cancer death in the developed world. Populationbased screening has been ineffective, but new approaches for early diagnosis and prevention that leverage molecular genomics are in development. Clinical ovarian and other gynecologic cancer journal. Incorporation of pazopanib in maintenance therapy of ovarian cancer. Epithelial ovarian cancer generally presents at an advanced stage and is the most common cause of gynaecological cancer death. Globocan 2012 iarc section of cancer information 54 2014 5. Most women have advanced disease international federation of gynecology and obstetrics figo stage iii, for which the standard of care remains surgery and platinumbased cytotoxic. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Natural history of ovarian cancer pubmed central pmc.
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